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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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A Catheter-Related Candida albicans Infection Model in Mouse
03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Candida infective endocarditis.

J W Baddley1, D K Benjamin, M Patel

  • 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0006, USA. jbaddley@uab.edu

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|February 20, 2008
PubMed
Summary
This summary is machine-generated.

Candida infective endocarditis (IE) is a rare but deadly condition. This study found Candida IE patients had more prosthetic valves, catheters, and healthcare infections, leading to higher mortality compared to non-fungal IE.

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Area of Science:

  • Infectious Diseases
  • Cardiology
  • Mycology

Background:

  • Candida infective endocarditis (IE) is a rare but frequently fatal condition.
  • Existing epidemiologic data on Candida IE are limited, primarily from small case series or reports.
  • Understanding the unique characteristics of Candida IE is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the epidemiology, treatment patterns, and outcomes of patients with Candida IE.
  • To compare the features and outcomes of Candida IE with non-fungal IE.
  • To identify risk factors and differences in surgical indications for Candida IE.

Main Methods:

  • Retrospective cohort study comparing 33 Candida IE cases with 2,716 non-fungal IE patients.
  • Data collected from the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) between June 2000 and August 2005.
  • Analysis of patient demographics, risk factors, reasons for surgery, treatment strategies, and mortality.

Main Results:

  • Candida IE patients were more likely to have prosthetic valves, indwelling catheters, and healthcare-associated infections.
  • Myocardial abscess and persistent positive blood cultures were more common reasons for surgery in Candida IE cases.
  • Mortality at discharge was significantly higher in Candida IE patients (30.3%) compared to non-fungal IE (17%).

Conclusions:

  • Candida IE exhibits distinct epidemiologic features and higher mortality compared to non-fungal IE.
  • Surgical intervention indications differ between Candida and non-fungal IE.
  • While newer antifungal drugs like echinocandins are increasingly used, mortality remains elevated, necessitating further large-scale research.