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Related Concept Videos

Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
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Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Updated: Jul 7, 2026

Auricular Point Acupressure Therapy: A Safe and Effective Treatment for Postsurgical Abortion Recovery
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Published on: February 3, 2026

Emergency contraception: a review.

Carlo Bastianelli1, Manuela Farris, G Benagiano

  • 1Department of Gynaecologic Sciences, Perinatology and Child Care, University la Sapienza, Rome, Italy. carlo.bastianelli@uniroma1.it

The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception
|February 20, 2008
PubMed
Summary
This summary is machine-generated.

Emergency contraception prevents pregnancy after unprotected sex. Levonorgestrel is more effective and has fewer side effects than older hormonal methods, while copper intrauterine devices offer highly effective, long-term prevention.

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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

Area of Science:

  • Reproductive Health
  • Pharmacology

Background:

  • Emergency contraception (EC) provides a crucial option for pregnancy prevention post-unprotected intercourse.
  • Both hormonal and intrauterine methods are available, with evolving efficacy and side effect profiles.

Purpose of the Study:

  • To review the development and comparative effectiveness of different emergency contraception modalities.
  • To highlight advancements in hormonal EC and the role of intrauterine devices.

Main Methods:

  • Review of historical development of hormonal EC regimens (Yuzpe, levonorgestrel, mifepristone).
  • Analysis of clinical trial data comparing efficacy and side effects of different EC methods.
  • Examination of intrauterine EC, specifically copper devices, for pregnancy prevention.

Main Results:

  • Levonorgestrel monotherapy is more effective and better tolerated than the older Yuzpe regimen.
  • Mifepristone-based regimens have also been explored by the WHO.
  • Copper intrauterine devices (IUDs) demonstrate very low pregnancy rates (0.1-0.2%) when used as EC, acting by preventing implantation.

Conclusions:

  • Levonorgestrel represents an improved hormonal EC option.
  • Copper IUDs offer a highly effective, albeit more complex, form of emergency contraception with a primary mechanism of preventing implantation.