Related Experiment Video
Updated: Jul 7, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Technical challenges facing therapeutic cancer vaccines
Stephen Ward1, John Copier, Angus Dalgleish
1Onyvax Ltd, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
Current Opinion in Drug Discovery & Development
|February 20, 2008
Summary
Therapeutic cancer vaccines for renal, colorectal, and prostate cancers show promise. This review covers cellular vaccine development progress and challenges in large-scale production for clinical trials and commercialization.
Area of Science:
- Oncology
- Immunology
- Biotechnology
Background:
- Therapeutic cancer vaccines are advancing, with notable progress in vaccines targeting renal, colorectal, and prostate cancers.
- Cellular vaccines represent a promising avenue in cancer immunotherapy.
Purpose of the Study:
- To review the progress in the development of cellular cancer vaccines.
- To identify and discuss the technical challenges hindering the advancement of these vaccines to Phase III clinical trials and commercial supply.
Main Methods:
- Literature review of recent advancements in cellular cancer vaccine development.
- Analysis of challenges in large-scale vaccine design, production, and scale-up.
- Examination of quality and yield assessment methodologies.
- Review of evolving regulatory guidelines for cellular vaccine production.
Main Results:
- Significant progress has been made in developing cellular vaccines for specific cancers.
- Key challenges include large-scale production, process scale-up, and consistent quality/yield assessment.
- Evolving regulatory guidelines are crucial for navigating clinical trials and commercialization.
Conclusions:
- Cellular cancer vaccines hold significant therapeutic potential.
- Overcoming manufacturing and regulatory hurdles is essential for successful clinical translation and market access.
- Continued research and development are vital for realizing the full potential of cancer vaccines.
More Related Videos
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
07:33Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
Published on: September 28, 2022
Related Concept Videos
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...