Inside SMP proteomics: six years German Human Brain Proteome Project (HBPP) - a summary
Michael Hamacher1, Tanja Hardt, Andre van Hall
1Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany. Michael.Hamacher@rub.de
Proteomics
|February 20, 2008
Summary
The German Brain Proteome Project (HBPP) developed technologies for analyzing the human brain
Area of Science:
- Neuroscience
- Proteomics
- Genomics
Background:
- Initiated by the German Federal Ministry of Education and Research (BMBF) in 2001, the National Genome Research Network (NGFN) established a multidisciplinary platform.
- The Human Brain Proteome Project (HBPP) operates within NGFN, focusing on human brain analysis in health and disease.
Purpose of the Study:
- To establish and optimize technology platforms for brain proteome analysis.
- To apply these technologies for research into Alzheimer's and Parkinson's diseases.
Main Methods:
- Development and optimization of technology platforms for proteomic analysis.
- Large-scale application of established technologies in HBPP2 (2004-2008).
Main Results:
- Successful establishment and optimization of necessary technologies during HBPP1 (2001-2004).
- Application of developed technologies in HBPP2 for large-scale experiments.
- Facilitating new research avenues and therapies for brain diseases.
Conclusions:
- The German Brain Proteome Project has successfully developed and applied advanced technologies for human brain proteome research.
- The project provides a foundation for further research into common human diseases and aging, particularly neurodegenerative disorders.
