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Updated: Aug 8, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor]
B Autran1, B Sadat-Sowti, P Debre
1Laboratoire d'Immunologie cellulaire et tissulaire, U.A.-C.N.R.S. n. 186, Paris.
Abstract:
We report a new suppressor function of CD8+CD57+ lymphocytes from HIV-seropositive patients or allotransplanted recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha beta. A preliminary biochemical characterization indicates that the CD8+CD57+ inhibitory activity 1. is heat and trypsin resistant, 2. specifically binds to Concanavalin A suggesting its glycosylation, 3. is mediated by a 20-30 kD molecule.
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