Related Experiment Video
Updated: Jul 7, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
Published on: July 15, 2025
Psychosocial and behavioral correlates of depressed mood among female methamphetamine users
Shirley J Semple1, Jim Zians, Steffanie A Strathdee
1Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0680, USA.
Abstract:
Female methamphetamine (meth) users report more depressive symptoms than do males. This study examined psychosocial and behavioral correlates of depressed mood in 146 heterosexual, meth-using women in San Diego, CA. Sixty percent met Beck Depression Inventory (BDI) criteria for moderate to severe depressive symptoms (i.e., higher levels of depressive symptoms); 40% had minimal to mild depressive symptoms (i.e., lower levels of depressive symptoms). The two groups were compared on background characteristics, reasons for meth use, patterns of meth use, psychosocial factors, social and sexual consequences of meth use, and sexual risk behavior. Women with higher levels of depressive symptoms were less likely to be employed, were more likely to use meth to cope with mood, used more grams of meth in a 30-day period, used meth more times per day on a greater number of consecutive days, and were more likely to be binge users of meth. They also scored lower on a measure of self-esteem and higher on measures of impulsivity, social stigma, and social network members' use of meth. In multivariate analyses, lower self-esteem and higher ratings of social network members' use of meth were significant predictors of higher levels of depressive symptoms. Psychosocial and behavioral factors are discussed in terms of treatment protocols for mood regulation and meth abatement in the target population.
Related Concept Videos
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Antidepressant Drugs: MAOIs and Other Agents
Depressive Disorders: MDD and Dysthymia
Depression: Overview
Psychological and Sociocultural Causes of Schizophrenia
