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Related Experiment Video

Updated: Jul 7, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Persistent erythema multiforme treated with thalidomide.

Chia-Wei Chen1, Tsen-Fang Tsai, Yu-Fu Chen

  • 1Department of Dermatology, Show Chwan Memorial Hospital, Taiwan, Republic of China.

American Journal of Clinical Dermatology
|February 21, 2008
PubMed
Summary
This summary is machine-generated.

Persistent erythema multiforme is a rare condition causing continuous skin lesions. A 15-year-old boy with this disorder showed significant improvement after thalidomide treatment.

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Last Updated: Jul 7, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Erythema multiforme (EM) is a common, self-limited skin disorder.
  • It presents with characteristic iris or target lesions on skin and mucous membranes.
  • Three clinical subgroups exist: classical, recurrent, and persistent EM.

Observation:

  • Persistent erythema multiforme is defined by continuous, uninterrupted lesions.
  • A 15-year-old male presented with a 6-month history of persistent EM.
  • The patient exhibited continuous typical and atypical lesions.

Findings:

  • The patient's persistent erythema multiforme responded effectively to thalidomide therapy.
  • Thalidomide demonstrated therapeutic efficacy in this case of persistent EM.
  • This case highlights a potential treatment option for persistent erythema multiforme.

Implications:

  • Thalidomide may be a viable treatment option for persistent erythema multiforme.
  • Further research into thalidomide for persistent EM is warranted.
  • Understanding treatment responses can improve management of rare dermatological conditions.