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Absorbable biomaterials used within paranasal sinuses: an animal study
Matthew R Stumpe1, Charles Handorf, Jerome W Thompson
1Department of Otolaryngology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
American Journal of Rhinology
|February 21, 2008
Summary
Hyaluronic acid (HA) dressings impact mucosal regeneration quality. HA-carboxymethyl cellulose (HACMC) showed better healing than esterified HA (HYAFF), with controls performing best.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oral and Maxillofacial Surgery
Background:
- Hyaluronic acid (HA) is used in resorbable dressings.
- Two HA derivatives, HA-carboxymethyl cellulose (HACMC) and esterified HA (HYAFF), were compared.
- Understanding their effect on mucosal regeneration is crucial.
Purpose of the Study:
- To investigate mucosal regeneration quality with HACMC and HYAFF dressings.
- To compare the efficacy of different HA-derived materials in sinus wound healing.
Main Methods:
- A prospective randomized animal study was conducted.
- Bilateral maxillary sinusotomies were performed in rabbits.
- Sinuses were packed with HACMC, HYAFF, or left as controls, followed by histological evaluation.
Main Results:
- Optimal mucosal regeneration was observed in 62.5% of HACMC, 12.5% of HYAFF, and 75% of control specimens.
- HACMC and control groups showed significantly better regeneration than HYAFF (p = 0.03).
- HYAFF dressings were associated with atrophic glands and foreign material presence.
Conclusions:
- The form of HA influences epithelial regeneration quality.
- Unpacked controls demonstrated the most optimal healing characteristics.
- HACMC dressings exhibited favorable healing patterns, comparable to controls.
