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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Acute Pancreatitis II: Pathophysiology

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Updated: Jul 7, 2026

A Plate-based Cytotoxicity Assay for the Assessment of Rat Placental Natural Killer Cell Cytolytic Function
10:44

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Published on: June 2, 2019

NK cells and pre-eclampsia.

Debra Goldman-Wohl1, Simcha Yagel

  • 1Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Mt Scopus, Jerusalem, 91240 Israel.

Reproductive Biomedicine Online
|February 21, 2008
PubMed
Summary
This summary is machine-generated.

Pre-eclampsia, a pregnancy disorder causing maternal and fetal mortality, may stem from issues with decidual natural killer (NK) cells. These immune cells are crucial for normal placental development and function.

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Area of Science:

  • Immunology
  • Obstetrics
  • Reproductive Medicine

Background:

  • Pre-eclampsia is a leading cause of maternal and fetal mortality and preterm birth.
  • This pregnancy disorder affects up to 10% of first-time mothers, presenting with hypertension and proteinuria.
  • Defective placentation and insufficient utero-placental blood flow are implicated in pre-eclampsia's pathogenesis.

Purpose of the Study:

  • To investigate the role of decidual natural killer (NK) cells in normal placentation.
  • To explore the potential link between decidual NK cell function and the placental pathologies observed in pre-eclampsia.

Main Methods:

  • Review of accumulating evidence from animal models.
  • Analysis of genetic studies.
  • Examination of data from isolated decidual leukocytes.

Main Results:

  • Decidual NK cells appear to supply essential factors for maternal-fetal interface development.
  • These cells play a role in the arterial modification of the maternal-fetal interface.
  • Evidence suggests a beneficial role of NK cells in normal placentation.

Conclusions:

  • Dysfunction or insufficient contribution of decidual NK cells may underlie placental pathologies in pre-eclampsia.
  • Understanding NK cell function offers insights into the etiology of pre-eclampsia.
  • Further research into decidual NK cells could illuminate therapeutic targets for pre-eclampsia.