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Updated: Jul 7, 2026

Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
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Lymphatic vessel density in radical prostatectomy specimens.

Liang Cheng1, Elena Bishop, Honghong Zhou

  • 1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. lcheng@iupui.edu

Human Pathology
|February 21, 2008
PubMed
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Lymphangiogenesis, the formation of new lymphatic vessels, is reduced within prostate tumors. This finding suggests that measuring lymphangiogenesis may not provide prognostic information for prostate cancer patients.

Area of Science:

  • Oncology
  • Pathology
  • Cancer Research

Background:

  • Lymphangiogenesis, the formation of new lymphatic channels, is linked to poor prognosis in various cancers.
  • The prognostic value of lymphangiogenesis in prostate cancer remains unclear.

Purpose of the Study:

  • To investigate the prognostic significance of lymphangiogenesis in prostate cancer.
  • To quantify lymphatic vessel density (LVD) in different prostate tissue compartments.

Main Methods:

  • Analysis of 122 radical prostatectomy specimens.
  • Immunohistochemistry using D2-40 antibody to detect lymphatic endothelium.
  • Comparison of LVD in intratumoral, peritumoral, and normal prostate tissues.

Main Results:

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  • Intratumoral LVD (3.0 vessels/field) was significantly lower than peritumoral (5.2) or normal (4.8) LVD (P < .001).
  • No significant difference in LVD between peritumoral and normal prostate tissues (P = .29).
  • Prostate LVD did not correlate with other clinical or pathological parameters.

Conclusions:

  • Lymphatic vessel density is decreased in the intratumoral prostate compartment compared to surrounding tissues.
  • Quantifying lymphangiogenesis in prostate cancer does not appear to offer prognostic value, unlike in other malignancies.