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Adenosine modulates oesophageal sensorimotor function in humans.

J M Remes-Troche¹, P Chahal, R Mudipalli

¹Department of Internal Medicine, Division of Gastroenterology-Hepatology, Section of Neurogastroenterology, University of Iowa Carver College of Medicine & Clinical Research Center, Iowa City, Iowa 52242, USA.

|February 21, 2008

Summary

This summary is machine-generated.

Adenosine infusion in healthy volunteers significantly lowered pain perception thresholds and decreased esophageal distensibility. These findings suggest adenosine plays a role in functional chest pain by altering esophageal sensorimotor function.

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Area of Science:

Gastroenterology
Neuroscience
Physiology

Background:

Adenosine is known to mediate pain but its role in gut visceral nociception is not well understood.
The specific effects of adenosine on esophageal sensorimotor function required investigation.

Purpose of the Study:

To investigate the hypothesis that adenosine alters esophageal sensorimotor function.
To assess adenosine's impact on visceral nociception in the esophagus.

Main Methods:

A double-blind, randomized, placebo-controlled study involving 14 healthy volunteers.
Intravenous administration of adenosine or placebo, followed by stepwise esophageal balloon distensions using impedance planimetry.
Assessment of sensory responses and biomechanical properties of the esophagus.

Main Results:

Adenosine significantly reduced thresholds for esophageal perception, discomfort, and pain compared to placebo.
Lowered median threshold pressures were observed for first perception, discomfort, and pain after adenosine infusion.
Adenosine increased esophageal cross-sectional area and stiffened the esophageal wall.

Conclusions:

Adenosine induces visceral hyperalgesia and reduces esophageal distensibility in humans.
The observed sensorimotor changes mimic those in patients with functional esophageal chest pain.
Adenosine modulates esophageal sensorimotor function and may contribute to the pathogenesis of functional chest pain.