Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Regulation of Bacterial Virulence01:28

Regulation of Bacterial Virulence

Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of on-site versus NOAA's extreme precipitation intensity-duration-frequency estimates for six forest headwater catchments across the continental United States.

Stochastic environmental research and risk assessment : research journal·2026
Same author

Adult mice with neonatal-like T cell subsets exhibit increased susceptibility to Bordetella pertussis and influenza infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

A Watershed-Scale Multi-Approach Assessment of Design Flood Discharge Estimates used in Hydrologic Risk Analyses for Forest Road Stream Crossings and Culverts.

Journal of hydrology·2026
Same author

Viral correlates of protection and the multifarious interactions of B and T cells.

Human vaccines & immunotherapeutics·2025
Same author

Bordetellae colonization oligosaccharide (b-Cool), a glycan crucial for nasal colonization.

Science advances·2025
Same author

A highly conserved sRNA downregulates multiple genes, including a σ<sup>54</sup> transcriptional activator, in the virulence mode of <i>Bordetella pertussis</i>.

mBio·2025

Related Experiment Video

Updated: Jul 7, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

O antigen protects Bordetella parapertussis from complement.

Elizabeth M Goebel1, Daniel N Wolfe, Kelly Elder

  • 1Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA.

Infection and Immunity
|February 21, 2008
PubMed
Summary

Bordetella parapertussis O antigen aids initial respiratory colonization by preventing complement-mediated killing. This protection is crucial for early infection stages in complement-sufficient hosts.

More Related Videos

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Related Experiment Videos

Last Updated: Jul 7, 2026

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Bordetella pertussis and Bordetella parapertussis cause whooping cough.
  • B. pertussis has BrkA for serum resistance, while B. parapertussis lacks it.
  • B. parapertussis produces O antigen, potentially conferring serum resistance.

Purpose of the Study:

  • To investigate the role of O antigen in B. parapertussis pathogenesis.
  • To determine if O antigen provides serum resistance and influences colonization and systemic spread.

Main Methods:

  • Murine model of B. parapertussis infection.
  • Comparison of wild-type and O antigen-deficient B. parapertussis strains.
  • Infection studies in complement-sufficient and complement-deficient mice.

Main Results:

  • O antigen facilitated B. parapertussis respiratory colonization during the first week of infection.
  • O antigen prevented complement component C3 deposition and complement-mediated killing.
  • O antigen was essential for systemic spread in complement-sufficient mice but not in complement-deficient mice.

Conclusions:

  • B. parapertussis O antigen is critical for early respiratory tract colonization.
  • O antigen protects against complement-mediated clearance, enabling bacterial survival and spread.