Related Experiment Video

Updated: Jul 7, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Thrombophilia differences in cerebral venous sinus and lower extremity deep venous thrombosis

E M Wysokinska1, W E Wysokinski, R D Brown

  • 1Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Neurology
|February 21, 2008
PubMed

Insights

Thrombophilia testing reveals distinct differences in clotting factors between cerebral venous sinus thrombosis (CVST) and deep vein thrombosis (DVT) patients. These variations may explain why venous thrombosis occurs in different locations.

Area of Science:

  • Medical research
  • Hematology
  • Vascular medicine

Background:

  • Cerebral venous sinus thrombosis (CVST) and deep vein thrombosis (DVT) are serious conditions.
  • Understanding the underlying causes, particularly thrombophilia, is crucial for diagnosis and treatment.
  • Previous studies have not extensively compared thrombophilic variables across these distinct venous thrombosis types.

Purpose of the Study:

  • To compare the prevalence of thrombophilic variables in patients with CVST versus those with lower extremity DVT.
  • To identify potential differences in risk factors that may influence the location of venous thrombosis.

Main Methods:

  • An inception cohort of 163 patients with first-time CVST (1995-2005) underwent comprehensive thrombophilia testing.
  • Test results were compared to a randomly selected group of patients with lower extremity DVT who also had comprehensive thrombophilia testing.

Main Results:

  • Thrombophilia was present in 29% of CVST patients.
  • Prothrombin G20210A mutation was significantly more common in CVST patients (11%) compared to DVT patients.
  • Factor V Leiden and protein C deficiency were more prevalent in DVT patients.

Conclusions:

  • The prevalence of specific thrombophilic factors differs between CVST and DVT.
  • These observed differences may provide insights into the mechanisms driving the geographic distribution of venous thrombosis.
Abstract

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Veins of Lower Limbs01:15

Veins of Lower Limbs

The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the knee,...