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Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study.

Hiroshi Watanabe1, Naohito Tanabe, Toru Watanabe

  • 1Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. hiroshi7@med.niigata-u.ac.jp

Circulation
|February 21, 2008

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View abstract on PubMed

Summary

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  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Metabolic Syndrome And Risk Of Development Of Atrial Fibrillation: The Niigata Preventive Medicine Study.
    • This summary is machine-generated.

    Metabolic syndrome, a cluster of risk factors, significantly increases the risk of developing atrial fibrillation (AF). Key components like obesity and high blood pressure are strongly linked to AF development.

    Area of Science:

    • Cardiology
    • Metabolic Health
    • Epidemiology

    Background:

    • Metabolic syndrome is a constellation of atherosclerotic risk factors.
    • These factors are implicated in atrial fibrillation (AF) genesis.
    • The specific role of metabolic syndrome in AF development remains unclear.

    Purpose of the Study:

    • To investigate the association between metabolic syndrome and the risk of new-onset atrial fibrillation (AF).
    • To evaluate the impact of individual metabolic syndrome components on AF development.
    • To compare the predictive value of two different metabolic syndrome definitions for AF risk.

    Main Methods:

    • Prospective, community-based, observational cohort study in Japan.
    • 28,449 participants without baseline AF underwent annual health check-ups.
    • Metabolic syndrome assessed using National Cholesterol Education Program Third Adult Treatment Panel (NCEP-ATP III) and American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) criteria.

    Main Results:

    • During a mean 4.5-year follow-up, 265 new cases of AF were diagnosed.
    • Metabolic syndrome components including obesity, elevated blood pressure, low HDL cholesterol, and impaired fasting glucose were associated with increased AF risk.
    • The association between metabolic syndrome and AF remained significant under the NCEP-ATP III definition, particularly in individuals without treated hypertension or diabetes.

    Conclusions:

    • Metabolic syndrome is a significant risk factor for the development of atrial fibrillation.
    • The metabolic dysregulation inherent in metabolic syndrome likely plays a crucial role in the pathogenesis of AF.

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