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[Cutaneo-mucosal hyperpigmentation in AIDS. 4 cases].

I Poizot-Martin1, A Lafeuillade, C Dhiver

  • 1Hôpital de jour du CISIH, Hôpital Salvator, Marseille.

Presse Medicale (Paris, France : 1983)
|April 13, 1991
PubMed
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Skin and mucous membrane pigmentation in homosexual men with HIV may stem from medications like azidothymidine, pyrimethamine, or ketoconazole. This highlights the importance of toxicological evaluation to avoid misdiagnosing adrenal insufficiency and prescribing harmful corticosteroids.

Area of Science:

  • Medical Science
  • Clinical Toxicology
  • Infectious Diseases

Background:

  • Cutaneo-mucosal pigmentation is a rare manifestation in patients with Human Immunodeficiency Virus (HIV) infection.
  • Previous reports suggest this pigmentation can mimic adrenal insufficiency, a serious endocrine disorder.

Observation:

  • This report details four cases of skin and mucous membrane pigmentation in homosexual men classified under the IVC1 group (CDC classification).
  • The patients presented with pigmentation, but showed no clinical or laboratory evidence of adrenal insufficiency.

Findings:

  • Aetiological investigation, though incomplete, suggested a potential medicinal origin for the observed pigmentation.
  • Specific drugs suspected include azidothymidine (AZT), pyrimethamine, and ketoconazole.

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Implications:

  • These findings underscore the necessity of comprehensive toxicological assessments in HIV-infected patients presenting with pigmentation.
  • Accurate diagnosis can prevent the inappropriate and potentially dangerous prescription of corticosteroid therapy in immunocompromised individuals.
  • Avoiding unnecessary corticosteroid use is crucial for patients with HIV who are susceptible to opportunistic infections.