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Related Experiment Video

Updated: Jul 7, 2026

Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
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Published on: March 15, 2021

Normal blood flow velocities of basal cerebral arteries decrease with advancing age: a transcranial Doppler

Seref Demirkaya1, Kayihan Uluc, Semai Bek

  • 1Department of Neurology, Gülhane Medical School, Ankara, Turkey.

The Tohoku Journal of Experimental Medicine
|February 21, 2008
PubMed
Summary
This summary is machine-generated.

Transcranial Doppler sonography (TCD) reveals that cerebral blood flow velocities significantly decrease with age. Establishing age-specific reference values for TCD is crucial for accurate clinical interpretation of results.

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Area of Science:

  • Neurosonology
  • Cerebrovascular Physiology

Background:

  • Transcranial Doppler (TCD) sonography assesses intracerebral blood flow non-invasively.
  • Normal cerebral hemodynamic parameters can be influenced by various factors, necessitating laboratory-specific reference values.
  • Establishing normative data is essential for precise TCD result interpretation.

Purpose of the Study:

  • To determine normal flow velocity values for basal cerebral arteries using TCD in a specific laboratory setting.
  • To investigate the impact of age and gender on these normal TCD values.

Main Methods:

  • Sixty-three healthy volunteers (30 male, 33 female; ages 5-69) were evaluated using TCD with a 2-MHz probe.
  • Subjects were categorized into seven age groups (5-10, 11-20, 21-30, 31-40, 41-50, 51-60, >60 years).
  • Mean velocity (V mean), peak systolic velocity (PSV), and end-diastolic velocities (EDV) were measured in the middle, anterior, and posterior cerebral arteries.

Main Results:

  • No significant differences in flow velocities were observed between genders.
  • A notable decrease in blood flow velocities across all measured arteries was found with increasing age.
  • These age-related decreases were statistically significant when comparing individuals over 40 years old to those 40 years old and younger.
  • Flow velocities were highest in the 5-10 year age group and lowest in those over 60 years old (p < 0.05).

Conclusions:

  • Cerebral blood flow velocities in basal arteries exhibit wide variability and are significantly influenced by age.
  • Accurate clinical interpretation of TCD data requires age-appropriate reference values.