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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Methotrexate-associated mantle-cell lymphoma in an elderly man with myasthenia gravis
Huy Tran1, Catherine Cheung, Devinder Gill
1Princess Alexandra Hospital, Brisbane, Australia.
Background:
A 75-year-old man on methotrexate immunosuppression for myasthenia gravis presented with a 2-month history of lymphocytosis and bilateral inguinal adenopathy. There were no constitutional symptoms of fever, night sweats, or weight loss.
Investigations:
Physical examination, blood tests, flow cytometry, fluorescent in situ hybridization, immunoglobulin gene sequencing, viral load quantification by real-time polymerase chain reaction, excisional lymph-node biopsy, bone-marrow biopsy, tumor morphology and immunohistochemistry, sequential CT and PET scans.
Diagnosis:
Methotrexate-associated mantle-cell lymphoma.
Management:
Cessation of methotrexate, anthracycline-based combination chemo-immunotherapy, and maintenance rituximab.
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