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Related Concept Videos

Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

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A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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Published on: May 27, 2021

Drug-drug interaction programs in clinical practice.

P A Pham1

  • 1Department of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA. vpham@jhmi.edu

Clinical Pharmacology and Therapeutics
|February 21, 2008
PubMed
Summary
This summary is machine-generated.

Clinicians often use drug interaction computer programs due to time limits. Understanding these tools' benefits and drawbacks is crucial for effective clinical practice management.

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Area of Science:

  • Clinical Pharmacology
  • Health Informatics

Background:

  • Numerous resources exist to assist with drug-drug interaction management.
  • Clinicians frequently depend on integrated computer programs to identify potential drug interactions.
  • Time constraints often hinder thorough evaluation of primary literature.

Purpose of the Study:

  • To highlight the importance of understanding the advantages and limitations of drug-interaction management tools.
  • To emphasize the reliance of healthcare providers on electronic programs for flagging drug interactions.

Main Methods:

  • Review of existing literature and electronic programs for drug-drug interaction management.
  • Analysis of the practical utility and constraints of these resources in clinical settings.

Main Results:

  • Drug-interaction computer programs are widely used by clinicians.
  • These programs offer significant aid in managing complex drug interactions.
  • Clinicians must be aware of the inherent limitations of these automated systems.

Conclusions:

  • Effective management of drug-drug interactions requires critical appraisal of available resources.
  • Understanding the strengths and weaknesses of drug-interaction software is essential for safe and efficient clinical practice.