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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

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Updated: Jul 7, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Pediatric sarcomas occurring in adults.

Robert G Maki1

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021-6007, USA. makir@mskcc.org

Journal of Surgical Oncology
|February 21, 2008
PubMed
Summary

Pediatric sarcomas, such as osteogenic sarcoma, Ewing sarcoma, and rhabdomyosarcoma, can affect adults and carry a higher mortality risk. This review discusses the management of these rare tumors.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Sarcoma Research

Background:

  • Sarcomas are rare cancers that can develop in any body part across all age groups.
  • Certain sarcomas predominantly affect children and are often linked to specific chromosomal translocations.
  • These pediatric-type sarcomas occurring in adults are associated with a higher risk of disease-related mortality compared to pediatric cases.

Purpose of the Study:

  • To review the management strategies for specific rare pediatric sarcomas that also occur in adults.
  • To highlight the distinct challenges and outcomes associated with these tumors in different age populations.

Main Methods:

  • Literature review focusing on osteogenic sarcoma, Ewing sarcoma, and rhabdomyosarcoma.
  • Analysis of disease characteristics and treatment outcomes in pediatric versus adult populations.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

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  • Discussion of current management approaches for these rare tumors.

    • Main Results:

    • Pediatric sarcomas, including osteogenic sarcoma, Ewing sarcoma, and rhabdomyosarcoma, present unique challenges when diagnosed in adults.
    • Adults diagnosed with these sarcomas often face a poorer prognosis compared to children.
    • Management strategies require careful consideration of tumor type, patient age, and specific prognostic factors.

    Conclusions:

    • Effective management of pediatric-type sarcomas in adults necessitates specialized approaches.
    • Further research is needed to improve outcomes for adults with these rare cancers.
    • Understanding the age-related differences in sarcoma presentation and progression is crucial for optimizing patient care.