Related Experiment Video
Updated: Jul 7, 2026
07:44
Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
Carcinomas arising in the submandibular gland: high propensity for systemic failure
Jong-Lyel Roh1, Seung-Ho Choi, Sang-Wook Lee
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Journal of Surgical Oncology
|February 21, 2008
Summary
Submandibular gland carcinomas are rare. Despite effective local treatment, about one-third of patients experience systemic failure, leading to poor survival, indicating a need for novel therapies.
Area of Science:
- Oncology
- Head and Neck Surgery
- Cancer Prognosis
Background:
- Submandibular gland carcinomas are uncommon malignancies.
- Limited data exists on patient survival and prognosis for these rare cancers.
Purpose of the Study:
- To evaluate treatment outcomes, locoregional control, and survival rates in patients with surgically treated submandibular gland carcinomas.
- To identify prognostic factors influencing disease-free and locoregional control.
Main Methods:
- Retrospective analysis of 62 patients with submandibular gland carcinomas treated surgically.
- Assessment of surgical excision with or without neck dissection, and postoperative radiotherapy.
- Kaplan-Meier method for survival rates and uni-/multivariate analyses for prognostic factors.
Main Results:
- Common subtypes included adenoid cystic (19), mucoepidermoid (11), and salivary duct carcinomas (10).
- Actuarial 5-year rates: locoregional control 69.7%, distant metastasis-free survival 65.8%, disease-free survival 52.8%, and overall survival 56.8%.
- T category and histological grading were prognostic for disease-free survival; T category and resection margins for locoregional control. Distant metastases occurred in 33.9% of patients.
Conclusions:
- Effective locoregional treatment for submandibular gland carcinomas is achievable.
- Systemic failure impacts survival in approximately one-third of patients.
- Novel therapeutic strategies are necessary to improve outcomes for these patients.
