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Updated: Jul 7, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Partial trisomy 1(q25qter) due to a de novo unbalanced 1;19 translocation in a neonate
1Department of Pediatrics, Duzce University School of Medicine, Duzce, Turkey. sensesdali@yahoo.com
Abstract:
We describe a male neonate with a duplication of 1(q25qter) due to de novo unbalanced translocation (1;19)(q25;pter). He had macrocephaly, wide sutures and wide anterior fontanelle, bilateral temporoparietal bossing, downward slanting palpebral fissures, low set, posteriorly rotated ears, downturned mouth corners, thin upper lip, retrognathia, high arched palate, triangular face, widely spaced nipples, bilateral single transverse palmar creases, bilateral partial syndactyly between second and third toes, ventricular dilatation, corpus callosum hypoplasia, and cavum septi pellucidi and cavum vergae, ventricular and atrial septal defects.
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