Related Experiment Video
Updated: Jul 7, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma
Jagadeesan Madhavan1, Anuradha Ganesh, Joseph Roy
1SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Purpose:
To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma.
Methods:
Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed.
Results:
Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors.
Conclusions:
Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.
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