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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time

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Gating at the selectivity filter in cyclic nucleotide-gated channels.

Jorge E Contreras1, Deepa Srikumar, Miguel Holmgren

  • 1Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3701, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 22, 2008
PubMed
Summary

Cyclic nucleotide-gated (CNG) channels, crucial for sensory signal transduction, are now shown to be gated at the selectivity filter. This finding challenges previous models and reveals a novel mechanism for ion channel regulation.

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