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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Adrenal function in patients with community-acquired pneumonia
S Gotoh1, N Nishimura, O Takahashi
1Dept of Respiratory Medicine, St Luke's International Hospital, Tokyo. gotoshin@luke.or.jp
The European Respiratory Journal
|February 22, 2008
Summary
Adrenal dysfunction is linked to community-acquired pneumonia severity. Higher pneumonia scores correlated with increased ACTH and cortisol, but reduced cortisol response, impacting patient outcomes.
Area of Science:
- Endocrinology
- Pulmonology
- Critical Care Medicine
Background:
- Adrenal insufficiency is common in sepsis.
- The relationship between adrenal function and community-acquired pneumonia (CAP) severity is not well understood.
Purpose of the Study:
- To investigate the association between adrenal function and CAP severity.
- To determine if adrenal dysfunction correlates with clinical outcomes in CAP patients.
Main Methods:
- 64 Japanese patients with CAP were enrolled.
- Serum adrenocorticotropic hormone (ACTH) and cortisol levels were measured.
- Cosyntropin stimulation test assessed cortisol response.
- Data correlated with Pneumonia Patient Outcomes Research Team (PORT) scores and clinical outcomes.
Main Results:
- Increasing PORT scores correlated with elevated serum ACTH and cortisol.
- Cortisol response to cosyntropin decreased as PORT scores increased.
- Adrenal dysfunction significantly correlated with in-hospital deaths and length of stay.
- True adrenal insufficiency via cosyntropin test was rare.
Conclusions:
- Adrenal dysfunction is associated with CAP severity and adverse clinical outcomes.
- Adrenal function markers may help predict CAP prognosis.
- Further research is needed to clarify the role of adrenal dysfunction in CAP.
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