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Screening for chronic kidney disease: where does Europe go?
Paul E de Jong1, Marije van der Velde, Ron T Gansevoort
1Department of Medicine, Division of Nephrology, University Medical Center Groningen, Hanzeplein 1, 9713 EZ Groningen, Netherlands. p.e.de.jong@int.umcg.nl
Clinical Journal of the American Society of Nephrology : CJASN
|February 22, 2008
Summary
Screening for chronic kidney disease (CKD) in Europe should include microalbuminuria testing to detect early stages (1 and 2), not just estimated glomerular filtration rate. Early detection is crucial for preventing renal and cardiovascular events.
Area of Science:
- Nephrology
- Public Health
- Preventive Medicine
Background:
- Chronic kidney disease (CKD) screening in Europe varies.
- Current methods often focus on estimated glomerular filtration rate (eGFR), missing early CKD stages.
Purpose of the Study:
- To review European CKD screening approaches.
- To highlight the importance of including microalbuminuria in screening protocols.
- To emphasize the benefits of early CKD detection for renal and cardiovascular health.
Main Methods:
- Review of existing European CKD screening programs and guidelines.
- Analysis of the diagnostic utility of eGFR and microalbuminuria.
- Evaluation of cost-effectiveness and target group strategies.
Main Results:
- CKD screening criteria differ across Europe, often limited to eGFR, thus identifying only stages 3+.
- Including microalbuminuria allows detection of CKD stages 1 and 2.
- Early CKD stages (1 and 2) carry significant risks for end-stage renal disease and cardiovascular events, comparable to stage 3.
Conclusions:
- CKD screening should incorporate microalbuminuria testing for comprehensive detection.
- Early identification of CKD stages 1 and 2 is vital for mitigating renal and cardiovascular risks.
- Preselection strategies using eGFR or albuminuria show effectiveness in European screening.
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