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Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
Published on: April 25, 2025
Algorithm for immediate cytologic diagnosis of hepatic tumors
Lawrence F Pupulim1, Michèle Felce-Dachez, Valérie Paradis
1Service de Radiologie, Hôpital Beaujon, Assistance Publique des Hôpitaux de Paris, Université Paris, 100, Blvd. du Général Leclerc, 92110 Clichy, France. law_dp@hotmail.com
AJR. American Journal of Roentgenology
|February 22, 2008
Summary
On-site cytologic evaluation of hepatic tumors offers high accuracy in detecting malignancy and specific subtypes like hepatocellular carcinoma and metastasis. This rapid assessment can potentially eliminate the need for further biopsies due to its reliable results.
Area of Science:
- Hepatobiliary pathology
- Cytopathology
- Oncology
Background:
- Immediate cytologic assessment of hepatic lesions aids specimen adequacy and preliminary diagnosis.
- Accurate and timely diagnosis of malignant hepatic lesions is crucial for patient management.
Purpose of the Study:
- To evaluate the diagnostic accuracy of on-site cytologic assessment versus definitive examination for detecting and subtyping malignant hepatic lesions.
- To compare the accuracy of immediate subtyping of hepatic tumors.
Main Methods:
- Analysis of 472 patients with hepatic nodules undergoing sonographically guided fine-needle aspiration and core biopsies.
- On-site cytologic analysis included preliminary diagnosis of malignancy and immediate subtyping when indicated.
Main Results:
- On-site analysis correctly identified 80.9% of malignant nodules (280/346) with no false positives.
- Immediate subtyping achieved detection rates of 68.1% for hepatocellular carcinoma, 77.8% for cholangiocarcinoma, and 85.0% for metastasis.
Conclusions:
- On-site cytologic evaluation demonstrates high diagnostic accuracy for malignancy in hepatic tumors.
- Specific diagnoses of common hepatic malignancies can be reliably made on-site.
- The high accuracy and lack of false positives suggest on-site assessment may obviate the need for additional biopsies, supporting a proposed cytohistopathologic management algorithm.
