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Related Experiment Video

Updated: Jul 7, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Imaging appearance of diffuse neurofibroma.

Douglass S Hassell1, Laura W Bancroft, Mark J Kransdorf

  • 1Department of Radiology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224-3899, USA. dshassell@gmail.com

AJR. American Journal of Roentgenology
|February 22, 2008
PubMed
Summary

Diffuse neurofibroma commonly presents as a plaquelike or infiltrative skin and subcutaneous lesion with prominent vascularity. This study reveals a broader distribution and association with neurofibromatosis than previously understood.

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Area of Science:

  • Radiology
  • Oncology
  • Dermatology

Background:

  • Diffuse neurofibroma is a rare soft tissue tumor.
  • Understanding its imaging characteristics and demographics is crucial for diagnosis and management.

Purpose of the Study:

  • To describe the imaging appearance of diffuse neurofibroma in a small cohort.
  • To summarize demographic data and tumor distribution in a larger patient group.

Main Methods:

  • Retrospective review of pathology and radiology databases from two institutions.
  • Analysis of imaging (MRI, CT, ultrasound) for 10 patients.
  • Demographic and clinical data collected for 339 patients.

Main Results:

  • Diffuse neurofibroma commonly involves skin and subcutaneous tissues, often extending to fascia.

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  • Plaquelike and infiltrative growth patterns were most frequent, with prominent internal vascularity.
  • A wider age and anatomical distribution, including extremities, trunk, and head/neck, was observed, with a notable association with neurofibromatosis.

    • Conclusions:

    • Diffuse neurofibroma typically presents as a plaquelike or infiltrative lesion in the skin and subcutaneous tissues.
    • Prominent internal vascularity is a common imaging finding.
    • The study highlights a broader distribution and increased association with neurofibromatosis than previously reported.