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Updated: Jul 7, 2026

Long-term Blood Pressure Measurement in Freely Moving Mice Using Telemetry
Published on: May 17, 2016
Animal models of hypertension
Brett M Mitchell1, Thomas Wallerath, Ulrich Förstermann
1Department of Internal Medicine Texas A&M Health Science, Center-College of Medicine Texas, USA.
Abstract:
Hypertension affects approximately 25% of adults and is a major risk factor for cardiovascular disease. Although there are currently adequate therapeutic options for humans with hypertension, the molecular mechanisms underlying hypertension are still relatively unknown. The generation of hypertensive animal models provides an excellent modality to not only study the pathophysiology but also test innovative therapeutics. This chapter describes the detailed methods that utilize the drinking water of rats to develop models of nitric oxide synthase (NOS) inhibition-induced, guanosine triphosphate cyclohydrolase (GTPCH) inhibition-induced, and glucocorticoid-induced hypertension.
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