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Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: Jul 7, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Target-based antimicrobial drug discovery.

Lefa E Alksne1, Paul M Dunman

  • 1Wyeth Research, Pearl River, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|February 22, 2008
PubMed
Summary
This summary is machine-generated.

The rise in antibiotic resistance necessitates new antibacterial drugs. Combining traditional screening with modern target-based methods may yield the next generation of treatments.

Related Experiment Videos

Last Updated: Jul 7, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Area of Science:

  • Microbiology
  • Pharmacology
  • Drug Discovery

Background:

  • Increasing antibiotic resistance in bacterial pathogens poses a significant global health threat.
  • A decline in pharmaceutical research for infectious diseases exacerbates the need for new treatments.
  • Current antibacterial agents are primarily derived from natural product screening, a method with diminishing returns.

Purpose of the Study:

  • To highlight the urgent need for novel antibacterial chemotherapies.
  • To discuss the shift from traditional screening to target-driven drug discovery.
  • To explore the potential of new methodologies, including genome-based approaches, in identifying new antibacterial agents.

Main Methods:

  • Review of current trends in antibacterial drug discovery.
  • Analysis of conventional whole-cell screening versus modern target-based approaches.
  • Discussion of emerging genome-based methodologies.

Main Results:

  • Traditional methods for discovering antibacterial agents are facing limitations.
  • Advances in target identification and assay development have spurred target-driven drug discovery.
  • The efficacy of genome-based methods in yielding novel antibacterial classes remains to be determined.

Conclusions:

  • A combination of traditional and novel drug discovery approaches may be crucial for developing the next generation of antibacterial treatments.
  • Synergy between established and emerging methodologies is essential to combat antibiotic resistance effectively.