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Roles of interleukin-1 and tumor necrosis factor in lipopolysaccharide-induced hypoglycemia
S N Vogel1, B E Henricson, R Neta
1Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Infection and Immunity
|July 1, 1991
Abstract:
In this study, hypoglycemia induced by injection of lipopolysaccharide (LPS) or the recombinant cytokine interleukin-1 alpha or tumor necrosis factor alpha (administered alone or in combination) was compared. LPS-induced hypoglycemia was reversed significantly by recombinant interleukin-1 receptor antagonist.