Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A genetic framework for improving arrhythmia therapy.

Björn C Knollmann1, Dan M Roden

  • 1Vanderbilt University School of Medicine, 1285 Medical Research Building IV, Nashville, Tennessee 37232, USA.

Nature
|February 22, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder.

Cardiovascular research·2026
Same author

Different actions of RyR2 open and closed channel block explained by a multiscale Ca<sup>2+</sup> release model.

Biophysical journal·2026
Same author

Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.

JACC. Clinical electrophysiology·2026
Same author

Dynamic-Structure Redesign of Calmodulin Reveals Mechanistic Constraints on Ryr2 Regulation.

bioRxiv : the preprint server for biology·2026
Same author

Entrectinib results in ventricular tachycardia and Brugada phenocopy through inhibition of sodium current.

Cardio-oncology (London, England)·2026
Same author

Structural Evaluation of <i>RYR2</i>-CPVT Missense Variants and Continuous Bayesian Estimates of Their Penetrance.

Circulation. Genomic and precision medicine·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
See all related articles

Identifying patients at risk for heart rhythm abnormalities and understanding their molecular causes are key to improving treatments. Studying genetic syndromes may reveal new ways to prevent and treat common arrhythmias.

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Heart rhythm abnormalities contribute significantly to morbidity and mortality.
  • Current treatment strategies are limited by challenges in early risk identification and understanding molecular mechanisms.

Purpose of the Study:

  • To explore how genetic syndromes influence susceptibility to arrhythmias.
  • To identify potential therapeutic targets for preventing and treating cardiac arrhythmias.

Main Methods:

  • Analysis of molecular pathways in individuals with genetic syndromes associated with arrhythmias.
  • Investigating mechanisms underlying increased arrhythmia risk.

Main Results:

  • Mechanisms identified that increase arrhythmia susceptibility in genetic syndromes.

Related Experiment Videos

  • Potential links between genetic factors and common arrhythmia pathways established.

    • Conclusions:

    • Understanding genetic underpinnings of arrhythmias can improve patient risk stratification.
    • Targeting molecular pathways in genetic syndromes may lead to novel therapies for common arrhythmias.