Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.

Nature communications·2026

Same author

The unexpected bright side of TNXIP in myocardial biology.

American journal of physiology. Heart and circulatory physiology·2026

Same author

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart.

bioRxiv : the preprint server for biology·2026

Same author

ERBB4 activation as a new therapy for atrial remodeling and fibrillation.

Heart rhythm·2026

Same author

The role of angiotensin II in cardiovascular disease-induced cancer growth.

Cardio-oncology (London, England)·2026

Same author

Assessing the retinal microvasculature in heart failure: A systematic review and possible clinical implications.

Microvascular research·2026

Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026

Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026

Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026

Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026

Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026

Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Stem-cell therapy for cardiac disease.

Vincent F M Segers¹, Richard T Lee

¹Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Facility, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.

|February 22, 2008

Summary

This summary is machine-generated.

Cell-based therapies show promise for treating heart failure, a leading cause of death. Stem cells may regenerate cardiac tissue, potentially reversing disease progression and improving heart function.

More Related Videos

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Published on: January 7, 2019

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Related Experiment Videos

Last Updated: Jun 23, 2026

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart

Published on: January 7, 2019

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Area of Science:

Regenerative Medicine
Cardiology
Stem Cell Biology

Background:

Heart failure is a major global health concern, with current treatments offering limited efficacy.
Existing therapies primarily manage symptoms and delay disease progression, highlighting the need for novel treatments.
Recent research indicates that cell-based therapies hold potential for improving cardiac function and regeneration.

Purpose of the Study:

To explore the potential of cell-based therapies in improving cardiac function.
To investigate the role of progenitor and resident cardiac stem cells in cardiac regeneration.
To assess the implications of these findings for preventing or reversing heart failure progression.

Main Methods:

Review of laboratory experiments and clinical trials on cell-based therapies for heart failure.
Analysis of studies on bone-marrow-derived progenitor cells and their differentiation into vascular cell types.
Examination of research on resident cardiac stem cells and their differentiation potential.

Main Results:

Cell-based therapies have demonstrated the ability to improve cardiac function.
Progenitor cells can differentiate into vascular cells, restoring blood flow.
Resident cardiac stem cells can differentiate into various cardiac cell types, including muscle cells, challenging the notion of terminal cardiac differentiation.

Conclusions:

The heart possesses regenerative potential through resident stem cells.
Cell-based therapies offer a promising avenue for preventing or reversing heart failure progression.
These findings stimulate optimism for developing effective treatments for heart failure.