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Updated: Jul 7, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Proinflammatory and oxidative stress markers in patients with periodontal disease
Ivan Borges1, Emília Addison Machado Moreira, Danilo Wilhem Filho
1Department of Nutrition, Federal University of Santa Catarina, 88040-970 Florianópolis, SC, Brazil.
Objective:
To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis.
Subject And Methods:
Eighteen subjects were divided in two groups: experimental (age 52.9+/-5.0) and control (age 51.1+/-9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test and P<.05.
Results:
Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05).
Conclusion:
The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
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