Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

PPAR Signaling in Placental Development and Function.

Yaacov Barak1, Yoel Sadovsky, Tali Shalom-Barak

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

PPAR Research
|February 22, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing Maternal and Infant Biospecimen Collection and Processing for Research.

Biopreservation and biobanking·2026
Same author

The Epigenetic Factor PHF13 Governs Trophoblast Stemness and Differentiation.

bioRxiv : the preprint server for biology·2026
Same author

Acoustic separation and isolation of viruses, small extracellular vesicles and other nanoscale bioparticles.

Nature protocols·2026
Same author

Macrophages rescue cells from ferroptotic death.

Cell death & disease·2025
Same author

miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.

Circulation·2025
Same author

The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunity.

Communications biology·2025
Same journal

Correction to "Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?"

PPAR research·2026
Same journal

Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis.

PPAR research·2026
Same journal

Metabolic Reprogramming and Immune Metabolism in Sepsis: Targeting the PPAR Pathway for Personalized Therapeutic Approaches.

PPAR research·2026
Same journal

Mediating Role of Muscle Mass in the Relationship Between Physical Activity and Bone Mass in Female University Students in China.

PPAR research·2026
Same journal

Correction to "Pemafibrate Pretreatment Attenuates Apoptosis and Autophagy During Hepatic Ischemia-Reperfusion Injury by Modulating JAK2/STAT3<i>β</i>/PPAR<i>α</i> Pathway".

PPAR research·2026
Same journal

The Mechanistic Role of PPAR<i>γ</i> in Wound Healing.

PPAR research·2026
See all related articles

Peroxisome proliferator-activated receptors (PPARs) are crucial for placental development and function. Research reveals their roles in cellular differentiation and tissue development beyond energy metabolism.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Biology

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are known for their roles in energy metabolism.
  • Their involvement in placental development was initially unexpected.
  • Understanding PPARs in the placenta offers insights into broader biological functions.

Purpose of the Study:

  • To review the essential functions of PPARgamma and PPARbeta/delta in placental development.
  • To explore the regulatory networks involving PPARs, RXR partners, coactivators, and target genes in placental biology.
  • To highlight the implications of these findings for trophoblast function and other cell types.

Main Methods:

  • Genetic studies, primarily using knockout animal models.

Related Experiment Videos

  • Pharmacological studies.
  • Cell culture experiments.

    • Main Results:

    • PPARgamma and PPARbeta/delta play essential roles in placental development and function.
    • Networks of PPARs, RXR partners, coactivators, and target genes regulate placental processes.
    • PPARs regulate cellular differentiation, tissue development, and trophoblast-specific functions.

    Conclusions:

    • The versatility of PPARs extends beyond metabolism to cellular differentiation and tissue development.
    • PPARs are critical regulators of placental biology.
    • Findings provide insights into PPAR functions in both placental and other cell types.