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Updated: Jul 7, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

[Constrictive pericarditis or restrictive cardiomyopathy? Echocardiographic tissue Doppler analysis]

T Butz1, L Faber, C Piper

  • 1Medizinische Klinik II (Kardiologie u. Angiologie), Marienhospital Herne, Klinikum der Ruhr-Universität Bochum, Herne. thomas.butz@marienhospital-herne.de

Deutsche Medizinische Wochenschrift (1946)
|February 22, 2008
PubMed

Insights

Tissue Doppler Imaging (TDI) effectively distinguishes constrictive pericarditis (CP) from restrictive cardiomyopathy (RCM). Mitral annular early diastolic velocity (E) measured by TDI is significantly higher in CP patients, aiding diagnosis.

Area of Science:

  • Cardiology
  • Echocardiography
  • Diastolic Dysfunction

Background:

  • Constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM) present with severe diastolic dysfunction.
  • Differentiating CP from RCM is crucial for appropriate management.
  • Echocardiographic tissue Doppler imaging (TDI) has been explored for this differentiation.

Purpose of the Study:

  • To analyze TDI parameters in patients with severe diastolic dysfunction.
  • To assess the utility of TDI in distinguishing between proven CP and RCM.

Main Methods:

  • Retrospective analysis of 34 patients (20 CP, 14 RCM).
  • Pulsed-wave TDI performed at mitral annulus (septal and lateral).
  • Invasive filling pressures were measured for correlation.

Main Results:

  • TDI early diastolic velocity (E) was significantly higher in CP than RCM (septal: 13.8 vs. 4.0 cm/s; lateral: 11.4 vs. 4.4 cm/s; p < 0.01).
  • A cut-off E velocity of 8 cm/s showed high sensitivity and specificity for RCM diagnosis.
  • E/E' ratio also differed significantly between CP and RCM groups.

Conclusions:

  • TDI measurement of mitral annular early diastolic velocity (E) can differentiate between CP and RCM.
  • TDI should be incorporated into routine echocardiographic evaluations for patients with diastolic dysfunction.
Abstract

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