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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Published on: October 1, 2007

Fluidic communication between multiple vertically segregated microfluidic channels connected by nanocapillary array

Maojun Gong¹, Bruce R Flachsbart, Mark A Shannon

¹Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Electrophoresis

|February 22, 2008

Summary

This summary is machine-generated.

Researchers developed hybrid microfluidic/nanofluidic devices using nanocapillary array membranes (NCAMs). A novel floating injection technique improves analyte control and separation resolution in these advanced microfluidic systems.

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Area of Science:

Microfluidics and Nanofluidics
Materials Science
Analytical Chemistry

Background:

Hybrid microfluidic/nanofluidic devices enable precise manipulation of small sample volumes.
Nanocapillary array membranes (NCAMs) offer controlled analyte transport between microfluidic channels.
Controlling analyte transport through NCAMs is achievable via ionic strength, electric bias, surface charge, and pore size.

Purpose of the Study:

To fabricate multilayer poly-(methyl methacrylate) microchips with integrated NCAMs.
To develop and evaluate a simplified floating injection technique for NCAM-coupled nanofluidic devices.
To compare the performance of floating injection with conventional biased injection.

Main Methods:

Fabrication of multilayer poly-(methyl methacrylate) microchips using adhesive contact printing.
Integration of nanocapillary array membranes (NCAMs) between microfluidic channel layers.
Implementation and comparison of floating injection versus biased injection techniques for analyte transfer.

Main Results:

Floating injection demonstrated superior plug reproducibility, separation resolution, and operational simplicity compared to biased injection.
Floating injection mitigates uneven analyte distribution issues sometimes seen with biased injection.
Potential for pressure-driven flow due to electroosmotic flow (EOF) mismatch in NCAMs with pore diameters < 50 nm requires consideration.

Conclusions:

Hybrid microfluidic/nanofluidic devices with NCAMs provide versatile platforms for sample analysis.
The floating injection technique offers significant advantages for specific applications requiring high resolution and reproducibility.
Careful consideration of fluid dynamics is necessary for optimal performance with sub-50 nm NCAM pores.