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Updated: Jul 7, 2026

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp
Ranjala Ratnayake1, Leith J Fremlin, Ernest Lacey
1Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Abstract:
An Australian estuarine isolate of an Acremonium sp. (MST-MF588a) yielded the two known compounds 19- O-acetylchaetoglobosin D ( 1) and 19- O-acetylchaetoglobosin B ( 2), as the sole cytotoxic principles, along with the known aromatic metabolite RKB 3564S ( 3), and a novel family of lipodepsipeptides, acremolides A-D ( 4- 7). Structures were assigned to 4- 7 on the basis of detailed spectroscopic analysis and chemical derivatization and by application of a new C 3 Marfey's method for amino acid analysis.
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