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Related Concept Videos

Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.
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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study

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Alkaloids from Daphniphyllum oldhami.

Shu-Zhen Mu1, Jun-Song Wang, Xiao-Sheng Yang

  • 1The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Guiyang 550002, People's Republic of China.

Journal of Natural Products
|February 22, 2008
PubMed
Summary

Four new Daphniphyllum alkaloids were discovered in Daphniphyllum oldhami, with one compound showing significant anti-platelet aggregation activity. This study also marks the first identification of quinolizidine alkaloids from this plant genus.

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • The genus Daphniphyllum is known for its diverse alkaloid content.
  • Isolation and characterization of novel compounds from natural sources are crucial for drug discovery.

Purpose of the Study:

  • To isolate and characterize new alkaloids from Daphniphyllum oldhami.
  • To investigate the anti-platelet aggregation activity of the isolated compounds.

Main Methods:

  • Spectroscopic methods, particularly 2D NMR techniques, were employed for structure elucidation.
  • Compounds were screened for their effects against platelet aggregation induced by Platelet-Activating Factor (PAF).

Main Results:

  • Four new Daphniphyllum alkaloids, daphnioldhanines H-K (1-4), were identified.
  • Thirty-four known alkaloids were also isolated, including dehydrodaphnigraciline (5) as a natural product.
  • Compound 3 demonstrated notable activity against PAF-induced platelet aggregation.

Conclusions:

  • This research expands the known chemical diversity of Daphniphyllum alkaloids.
  • The discovery of quinolizidine alkaloids in this genus is a significant finding.
  • Compound 3 shows potential as a lead for developing anti-platelet aggregation agents.