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Related Concept Videos

Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:

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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy
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Detection of Ligand-activated G Protein-coupled Receptor Internalization by Confocal Microscopy

Published on: April 9, 2017

CB receptor ligands from plants.

Karin Woelkart1, Outi M H Salo-Ahen, Rudolf Bauer

  • 1Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, 8010 Graz, Austria.

Current Topics in Medicinal Chemistry
|February 22, 2008
PubMed
Summary
This summary is machine-generated.

This review explores plant-derived cannabinoid ligands, highlighting their potential therapeutic and immunomodulatory effects. Discover how natural compounds like THC and Echinacea alkamides interact with cannabinoid receptors for various health benefits.

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Area of Science:

  • Pharmacology and Physiology
  • Immunology
  • Natural Product Chemistry

Background:

  • The endogenous cannabinoid system is a key target for therapeutic interventions.
  • Cannabinoids modulate immune cells and show promise for CNS inflammation, arthritis, and multiple sclerosis.
  • Endocannabinoids regulate mood, pain, energy balance, and neurological functions.

Purpose of the Study:

  • To review the current state of knowledge on cannabinoid (CB) ligands derived from plants.
  • To explore the therapeutic and immunomodulatory potential of these natural compounds.

Main Methods:

  • Literature review focusing on plant-derived CB ligands.
  • Analysis of pharmacological and physiological effects of cannabinoids.
  • Examination of immunomodulatory properties and therapeutic applications.

Main Results:

  • Plants offer diverse chemical structures for developing effective CB ligands.
  • Cannabis sativa L. (Delta(9)-tetrahydrocannabinol) and Echinacea species (alkamides) are prominent examples.
  • These ligands interact with cannabinoid receptors, influencing various physiological processes.

Conclusions:

  • Plant-derived cannabinoid ligands represent a promising area for drug discovery.
  • Further research into these natural compounds could yield novel treatments for inflammatory, autoimmune, and neurological disorders.