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Updated: Jul 7, 2026

Cellular Redox Profiling Using High-content Microscopy
Published on: May 14, 2017
Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model
Min Li1, Ao-Jin Wang, Jian-Xing Xu
1Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.
Abstract:
In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H(2)O(2) generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.
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