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Published on: May 13, 2020
Crystallization and preliminary x-ray analysis of anti-obesity peptide hormone oxyntomodulin
Pengyun Li1, Tanya Rogers, David Smiley
1Department of Chemistry and Biochemistry Program, Indiana University, Bloomington, Indiana 47405, USA.
Protein and Peptide Letters
|February 22, 2008
Abstract:
Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 A resolution and belongs to space group P2(1)3 with unit-cell parameters a=b=c= 48.44 A, alpha=beta=gamma=90 degrees . Preliminary analysis indicates a trimer packing in one asymmetric unit.
