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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

[Changes of serum creatine kinase levels in children with Duchenne muscular dystrophy]

Shun-Chang Sun1, Yun-Sheng Peng, Jing-Bo He

  • 1Department of Clinical Laboratory, People's Hospital of Bao'an District of Shenzhen, Shenzhen, Guangdong 518101, China. shunchangsun@sohu.com

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 22, 2008
PubMed

Insights

Serum creatine kinase (CK) levels peak in children with Duchenne muscular dystrophy (DMD) between ages 3-5. CK levels then decline with age, potentially indicating muscle degeneration in DMD patients.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Genetics

Context:

  • Duchenne muscular dystrophy (DMD) is a severe genetic disorder affecting young children.
  • Serum creatine kinase (CK) is a biomarker whose activity fluctuates with disease progression and age in DMD patients.

Purpose:

  • To investigate the age-related patterns of serum creatine kinase (CK) activity in children diagnosed with Duchenne muscular dystrophy (DMD).

Summary:

  • Serum CK levels were analyzed in 40 DMD patients aged 3-14 years.
  • A significant elevation in serum CK was observed compared to reference values.
  • Peak CK activity occurred in 3-5 year olds, followed by an average annual decline of 8.7%.

Impact:

  • Findings reveal a characteristic pattern of serum CK changes in pediatric DMD.
  • This pattern may serve as an indicator of muscle tissue breakdown rate in Duchenne muscular dystrophy.
Abstract

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