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Related Concept Videos

X-linked Traits01:19

X-linked Traits

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
X-linked Traits01:19

X-linked Traits

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Pedigree Analysis01:35

Pedigree Analysis

Overview
Primary Motives: Sleep, Sex, and Pain Avoidance01:24

Primary Motives: Sleep, Sex, and Pain Avoidance

Primary motives such as sleep, sex, and pain avoidance are crucial drivers of behavior in humans and animals. These motives ensure survival, reproductive success, and overall well-being by prompting actions that meet essential bodily needs.
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

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Related Experiment Video

Updated: Jul 7, 2026

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies
05:49

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Migraine: sex-influenced trait model?

Xiao-Ping Wang1, Jian-Min Liu, Yong-Bo Zhao

  • 1Department of Neurology, Shanghai first People's Hospital, Shanghai Jiao-Tong University, Shanghai, PR China. wangxp@ustc.edu

Medical Hypotheses
|February 22, 2008
PubMed
Summary

This study suggests migraine genetics are sex-influenced, potentially following an autosomal dominant pattern in females and autosomal recessive in males. Hormonal factors likely play a key role in migraine prevalence and transmission.

Related Experiment Videos

Last Updated: Jul 7, 2026

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies
05:49

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies

Published on: November 1, 2024

Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Migraine is a prevalent neurological disorder affecting 5-19% globally.
  • Existing evidence suggests a potential sex-influenced genetic component in migraine transmission.

Purpose of the Study:

  • To investigate a sex-influenced genetic model for migraine inheritance.
  • To explore the role of sex hormones in migraine prevalence and transmission patterns.

Main Methods:

  • Review of existing evidence including familial hemiplegic migraine genetics.
  • Analysis of epidemiological data on migraine prevalence by sex.
  • Consideration of factors like age of onset, hormonal influences (contraception, menstruation, menopause), and family studies.

Main Results:

  • Evidence supports a sex-influenced model: autosomal dominant in females and autosomal recessive in males.
  • Migraine prevalence is higher in females (1:2-4 male to female ratio).
  • Factors like early onset, hormonal contraception, menstruation, and menopause further support a sex-influenced genetic hypothesis.

Conclusions:

  • Migraine inheritance appears to be multi-factorial and sex-influenced.
  • Female sex hormones are hypothesized as a key factor, similar to androgens in male pattern baldness.
  • Environmental and cultural factors also contribute to migraine's complex inheritance.