Migraine: sex-influenced trait model?
Related Experiment Video
Updated: Jul 7, 2026

An Automated Squint Method for Time-syncing Behavior and Brain Dynamics in Mouse Pain Studies
Published on: November 1, 2024
Xiao-Ping Wang1, Jian-Min Liu, Yong-Bo Zhao
1Department of Neurology, Shanghai first People's Hospital, Shanghai Jiao-Tong University, Shanghai, PR China. wangxp@ustc.edu
Abstract:
Migraine is a periodic disorder with a worldwide prevalence of 5-19%. This study raises the hypothesis of a sex-influenced genetic model of migraine transmission. That migraine may be sex-influenced (autosomal dominant in females and autosomal recessive in males) is supported by such evidences as: (1) familial hemiplegic migraine, subtype from migraine with aura, being dominantly assigned to autosomal chromosome 19p, 1q, and 2q; (2) a male to female prevalence of 1:2-4; (3) primarily young age of onset; (4) provocation by pharmaceutical contraception; (5) induction by menstruation; (6) self-limitation after menopause; and (7) only female migraineurs in some migraine families. Female sex hormone in the migraineur may be the key factor, comparable to the male sex hormone: androgen, in the genetic baldness. Migraine appears caused by a multi-factor inheritance with higher rates among females than males, and influenced by environmental and cultural factors.
Related Concept Videos
X-linked Traits
X-linked Traits
Pedigree Analysis
Primary Motives: Sleep, Sex, and Pain Avoidance
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Sex Linked Disorders