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A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

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The concentric-ring phased-array hyperthermia applicator: problems associated with directly synthesized annular

M S Ibbini¹, C A Cain

¹Bioacoustics Res. Lab., Illinois Univ., Urbana, IL.

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

|January 1, 1989

Summary

Synthesizing ultrasonic annular patterns requires careful size selection. Larger patterns avoid axial hot spots but may not evenly heat tumor centers, impacting therapeutic ultrasound applications.

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Area of Science:

Acoustics
Biomedical Engineering
Medical Imaging

Background:

High-Intensity Focused Ultrasound (HIFU) utilizes focused ultrasonic energy for therapeutic applications, such as tumor ablation.
The precise control of ultrasonic energy deposition is crucial for effective and safe treatment.
Annular arrays are commonly used in therapeutic ultrasound for their focusing capabilities.

Purpose of the Study:

To investigate the synthesis of different sized annular patterns in ultrasonic fields.
To examine the relative intensities produced proximal and distal to the focal plane.
To determine the optimal size of annular patterns for avoiding excessive energy accumulation and achieving uniform heating.

Main Methods:

Computer simulations were performed using a concentric-ring array.
The size and position of synthesized annular patterns were varied by adjusting the phase and amplitude of the driving signal to each array element.
Analysis focused on energy distribution along the array axis and temperature distributions at the focal plane.

Main Results:

Annular patterns larger than a limiting size (Rs) are necessary to prevent excessive energy accumulation along the array axis.
Smaller annular patterns (r ≤ Rs) result in intense "hot spots" along the axis beyond the focal plane.
Larger annular patterns (r ≥ Rs) achieve therapeutic temperatures at the periphery but struggle to evenly raise the tumor center temperature.

Conclusions:

The size of synthesized annular patterns significantly influences ultrasonic energy distribution and thermal profiles.
A critical size (Rs) exists for annular patterns to mitigate axial energy deposition.
Optimizing annular pattern size is essential for achieving uniform therapeutic heating in targeted tissues, though challenges remain for uniform tumor center heating.