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Related Experiment Video

Updated: Jul 7, 2026

Angiogenesis in the Ischemic Rat Lung

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

Lactate, with oxygen, incites angiogenesis.

Thomas K Hunt¹, Rummana Aslam, Zamir Hussain

¹Department of Surgery, University of California Medical Center, San Francisco, CA 94143, USA.

Advances in Experimental Medicine and Biology

|February 23, 2008

Summary

Lactate accumulation, even with oxygen present, triggers key signals for new blood vessel growth (angiogenesis) and tissue repair. This finding challenges previous understandings of lactate's role in the body.

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Last Updated: Jul 7, 2026

Angiogenesis in the Ischemic Rat Lung

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Published on: February 8, 2013

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Published on: June 30, 2023

Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia

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Published on: June 8, 2019

Area of Science:

Biochemistry
Cell Biology
Physiology

Background:

Lactate was traditionally considered a byproduct of anaerobic metabolism.
Recent evidence suggests lactate production can occur under aerobic conditions.

Purpose of the Study:

To investigate the role of lactate accumulation in promoting angiogenesis and connective tissue deposition.
To explore the signaling pathways involved in lactate-induced tissue responses.

Main Methods:

A mini-review of current literature.
Experimental data involving subcutaneous implantation of Matrigel with a slow-release lactate source in mice.
Assessment of vascular endothelial growth factor (VEGF) and angiogenesis in oxygenated tissues.

Main Results:

Lactate accumulation was observed in the presence of oxygen.
Lactate instigated signaling for angiogenesis and connective tissue deposition.
Increased VEGF and angiogenesis were noted in oxygenated sites with added lactate.

Conclusions:

Lactate plays a significant role in aerobic conditions, promoting angiogenesis and tissue repair.
Lactate acts as a signaling molecule, influencing factors like VEGF, TGF-beta, IL-1, and HIF-1alpha.
This challenges the traditional view of lactate as solely an anaerobic metabolite.