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Related Experiment Video

Updated: Jul 7, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Congenital immunodeficiency disorder.

N Abhilash¹, S Radhakrishnan, M V Arun

¹Department of Medicine, Medical College, Calicut.

The Journal of the Association of Physicians of India

|February 23, 2008

Summary

This summary is machine-generated.

A 17-year-old girl with recurrent pneumonia and cold abscesses was diagnosed with hyper IgE syndrome. This rare condition, also known as Job's syndrome, involves immune system dysfunction.

Related Experiment Videos

Last Updated: Jul 7, 2026

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Simultaneous Quantification of T-Cell Receptor Excision Circles (TRECs) and K-Deleting Recombination Excision Circles (KRECs) by Real-time PCR

Published on: December 6, 2014

Area of Science:

Immunology
Pediatrics
Genetics

Background:

Hyperimmunoglobulin E syndrome (HIES), or Job's syndrome, is a primary immunodeficiency characterized by eczema, recurrent staphylococcal infections, and elevated serum IgE.
This rare genetic disorder affects multiple organ systems, leading to a range of clinical manifestations.

Observation:

A 17-year-old female student presented with a two-month history of fever and productive cough.
She had a history of recurrent pneumonia and soft tissue "cold abscesses" since the neonatal period.
Clinical examination and radiological findings were suggestive of an underlying immune disorder.

Findings:

Laboratory investigations revealed significantly elevated serum IgE levels.
The patient's clinical presentation and laboratory findings were consistent with a diagnosis of hyperimmunoglobulin E syndrome (Job's syndrome).

Implications:

Early diagnosis and management of Job's syndrome are crucial for preventing severe complications and improving patient outcomes.
This case highlights the importance of considering rare immunodeficiencies in the differential diagnosis of recurrent infections in adolescents.
Further research into the genetic basis and therapeutic strategies for HIES is warranted.