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Prevalence of glucose-6-phosphate dehydrogenase deficiency in Northern Greece

G Ntaios1, A Chatzinikolaou, C Tomos

  • 1First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. ntaiosgeorge@yahoo.gr

Internal Medicine Journal
|February 23, 2008
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Northern Greece, affecting 6.3% of the screened population. This study highlights a higher prevalence in males and suggests a significant public health concern in the region.

Area of Science:

  • Medical Genetics
  • Biochemistry

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a global health issue affecting over 400 million people.
  • Prevalence varies significantly across geographic and demographic groups.

Purpose of the Study:

  • To determine the prevalence of G6PD deficiency in Northern Greece.
  • To compare regional prevalence with the general Greek population.

Main Methods:

  • Screened 5161 newborns and adults between July 2001 and March 2007.
  • Utilized the dye reduction method for G6PD deficiency detection.

Main Results:

  • Identified a 6.3% overall prevalence of G6PD deficiency.
  • Moderate deficiency found in 2.7% and complete deficiency in 3.7% of subjects.
  • Prevalence in males was nearly double that in females.

Conclusions:

  • Northern Greece exhibits a higher prevalence of G6PD deficiency than the general Greek population.
  • The higher prevalence in males warrants further investigation and targeted health strategies.

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