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Updated: Jul 7, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Mechanisms for decreased function of B cells in aged mice and humans
Daniela Frasca1, Ana Marie Landin, Richard L Riley
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
Abstract:
The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.
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