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Updated: Jul 7, 2026
06:45
Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 18, 2010
Properdin plays a protective role in polymicrobial septic peritonitis.
Cordula M Stover1, Jeni C Luckett, Bernd Echtenacher
1Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK. cms13@le.ac.uk
Journal of Immunology (Baltimore, Md. : 1950)
|February 23, 2008
Summary
Properdin is crucial for fighting infections. Mice lacking properdin show impaired survival in polymicrobial sepsis, highlighting its role in the immune response.
Area of Science:
- Immunology
- Microbiology
Background:
- Properdin positively regulates complement activation.
- It is essential for defense against Neisseria meningitidis infections.
Purpose of the Study:
- To investigate the role of properdin in polymicrobial sepsis.
- To characterize a novel properdin-deficient mouse model.
Main Methods:
- Gene-specific targeting to create properdin-deficient mice.
- In vitro complement activation assays with Escherichia coli.
- In vivo polymicrobial sepsis model (cecal ligation and puncture).
Main Results:
- Properdin-deficient serum showed impaired complement fragment C3b generation.
- Properdin-deficient mice exhibited significantly reduced survival in sepsis.
- Properdin was found to localize to mast cells and associate with E. coli.
Conclusions:
- Properdin is vital for host defense against polymicrobial sepsis.
- The study establishes a new mouse model for properdin research.
- Properdin's role extends beyond Neisseria infections to broader immune responses.
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