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Related Experiment Videos

Modeling cell interactions under flow.

Claude Verdier1, Cécile Couzon, Alain Duperray

  • 1Laboratoire de Spectrométrie Physique, UMR 5588, CNRS and Université Grenoble I, 140 avenue de la physique, BP 87, 38402, Saint-Martin d'Hères Cedex, France. verdier@ujf-grenoble.fr

Journal of Mathematical Biology
|February 23, 2008
PubMed
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This review details how leukocytes and tumor cells interact with the endothelium, influenced by flow conditions, adhesion, and cell properties. Mathematical models aid in understanding these complex cell-cell adhesion dynamics.

Area of Science:

  • Biomedical Engineering
  • Cellular Biology
  • Fluid Dynamics

Background:

  • Cellular interactions with the endothelium are crucial in physiological and pathological processes like inflammation and metastasis.
  • Understanding these interactions requires considering factors such as blood flow, cell adhesion properties, and microrheology.
  • Existing models often simplify the complex interplay between cellular mechanics and fluid dynamics.

Purpose of the Study:

  • To review the current understanding of cell-endothelium interactions under various blood flow conditions.
  • To discuss the mechanisms of cell adhesion, including rolling, spreading, and migration.
  • To present and evaluate mathematical models that capture these interaction dynamics.

Main Methods:

  • Literature review of cell-endothelium interaction mechanisms.

Related Experiment Videos

  • Analysis of the influence of shear stress and microrheological properties on cell adhesion.
  • Examination of mathematical modeling approaches, including a novel viscoelastic drop model.
  • Comparison of model predictions with in vitro experimental data.

    • Main Results:

    • Cell-endothelium interactions are modulated by cell-cell adhesion, shear stress, and cell microrheology.
    • Specific adhesion proteins mediate distinct interaction mechanisms during inflammation and metastasis.
    • Flow conditions, including microfluidic effects, significantly impact cell adhesion dynamics.
    • A new model combining kinetic adhesion theory and viscoelastic cell mechanics shows qualitative agreement with experiments.

    Conclusions:

    • The review synthesizes current knowledge on cell-endothelium interactions, highlighting the importance of biomechanical factors.
    • Mathematical modeling provides valuable insights into the complex mechanisms governing cell adhesion and migration.
    • The presented viscoelastic drop model offers a promising framework for future research in this area.